About Amgen

At Amgen, we are committed to advancing science and developing treatments for patients with serious illnesses, including many rare diseases like Thyroid Eye Disease (TED). There are more than 10,000 different rare diseases impacting 400 million people globally. Rare diseases are complex and often underserved. They demand urgent attention and are a core and growing part of Amgen’s mission to serve patients.

TEPEZZA® (teprotumumab-trbw) is the first FDA-approved treatment for TED, no matter if you’ve had TED for months or years. Backed by 4 published clinical trials, 5 years of real-world experience and nearly 25,000 patients treated*, TEPEZZA can reduce eye bulging and improve double vision. TEPEZZA treats a source of TED, not just the symptoms. Infusion reactions can happen during or within 24 hours after your infusion of TEPEZZA. Please see additional Important Safety Information below.

*Based on 24,132 individual patients enrolled in Amgen By Your Side who received at least one dose of TEPEZZA from 02/05/2020 – 08/23/2025. TED diagnosis is assumed based on initiation of TEPEZZA.

5+ Years of Impact With TEPEZZA® (teprotumumab-trbw)

IMPORTANT SAFETY INFORMATION

What is the most important information I should know about TEPEZZA?

Infusion reactions can happen during or within 24 hours after your infusion of TEPEZZA. If you have a reaction while receiving TEPEZZA, your doctor or nurse will slow or stop your infusion and treat your reaction. If you have a severe infusion reaction, your doctor may stop your treatment completely.

Tell your doctor or nurse right away if you have any of these symptoms during or after your treatment with TEPEZZA:

• High blood pressure
• Fast heartbeat
• Redness of the face/Feeling hot
• Difficulty breathing
• Headache
• Muscle pain

TEPEZZA may worsen inflammatory bowel disease (IBD), such as Crohn’s disease or ulcerative colitis, even if you don’t have a diagnosis of IBD before starting TEPEZZA treatment. Tell your doctor right away if you have worsening IBD symptoms, which may include diarrhea with stomach pain or cramps, blood in your stools, sudden urgency to have a bowel movement, or feeling like you need to have a bowel movement even when there’s little or no stool to pass.

TEPEZZA may cause an increase in your blood sugar. Before starting treatment with TEPEZZA, tell your doctor if you are currently being treated for diabetes, know your blood sugar is high, or have been diagnosed with diabetes. It is important for you to take your treatments and follow an appropriate diet for glucose control as prescribed by your doctor.

TEPEZZA may cause severe hearing problems including hearing loss, which in some cases may be permanent. Tell your doctor if you have any signs or symptoms of hearing problems or changes in hearing.

Before receiving TEPEZZA, tell your doctor if you: 

• Have inflammatory bowel disease (Crohn’s disease or ulcerative colitis).
• Are currently being treated for diabetes, have been diagnosed with diabetes, or know your blood sugar is high.
• Are pregnant or plan to become pregnant. TEPEZZA may harm your unborn baby. Tell your doctor if you become pregnant or suspect you are pregnant during treatment with TEPEZZA.
  • Women who are able to become pregnant should use an effective form of birth control (contraception) prior to starting treatment, during treatment and for at least 6 months after the final dose of TEPEZZA.
• Are breastfeeding or plan to breastfeed. It is not known if TEPEZZA passes into your breast milk. Talk to your doctor about the best ways to feed your baby during treatment with TEPEZZA.
• Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, dietary and herbal supplements. Know the medicines you take. Keep a list of them to show your doctor and pharmacist when you get a new medicine.

What are the possible side effects of TEPEZZA?

The most common side effects of TEPEZZA include muscle cramps or spasms, nausea, hair loss, diarrhea, feeling tired, high blood sugar, hearing problems, taste changes, headache, dry skin, ear discomfort, weight loss, nail problems, and changes in menstruation.

This is not a complete list of all possible side effects. Tell your doctor or treatment team about any side effect you may have.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/safety/medwatch, or call 1-800-FDA-1088.

Please see Full Prescribing Information or visit TEPEZZA.com for more information.

Contact Amgen

General inquiries: rareconnect@amgen.com

Medical inquiries: medinfo@amgen.com

USA-632-80964 10/25